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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T80951	Trevogrumab REGN-1033
	Trevogrumab (REGN-1033) 是针对GDF8（即生长分化因子8，亦称为肌肉生长抑制素）的单克隆抗体。该化合物目前主要用于研究包括废用性萎缩、慢性疾病以及饮食及营养摄入变化等原因引起的肌肉减少症。

化合物

Trevogrumab

Cat.No: T80951

Synonym: REGN-1033

Target:

Species：

Expression System：

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Cat. No.	Product Name	Species	Expression System
TMPJ-00663	GDF-8 Protein, Human/Mouse/Rat, Recombinant 骨肉瘤源生长因子,Gdf8,Mstn,GDF-8,Growth/<...	Human,Mouse,Rat	HEK293 Cells
	Growth/differentiation factor 8(Mstn, GDF-8) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. It is expressed specifically in developing and adult skeletal muscle. It exists as a homodimer, and interacts with WFIKKN2, leading to inhibit its activity. This protein can act specifically a...
TMPJ-00966	GDF-5 Protein, Human, Recombinant Lipopolysaccharide-associated protein 4,Cartilage-derived mo...	Human	E. coli
	Growth Differentiation Factor 5(GDF-5, BMP-14) is a member of the BMP family of TGFβ superfamily proteins. Human GDF-5, -6, and -7 are a defined subgroup of the BMP family. GDF-5 is synthesized as a homodimeric precursor protein consisting of a 354 amino acid (aa) Nterminal proregion and a 120 aa C-terminal mature peptide. Mature human GDF-5 shares 99% aa sequence identity with both mature mouse and rat GDF-5. GDF-5 signaling is mediated by formation of a heterodimeric complex consisting of a ty...
TMPY-04123	CEACAM1 Protein, Human, Recombinant (His & hFc) CEACAM‑1,carcinoembryonic antigen-related cell adhesion mole...	Human	HEK293 Cells
	CEACAM1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 71.4 kDa and the accession number is P13688-8.
TMPJ-00808	CD45RA Protein, Human, Recombinant (His) PTPRC,CD45R,CD45,LCA,protein tyrosine phosphatase, receptor ...	Human	HEK293 Cells
	CD45RA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 100-135 KDa and the accession number is P08575-8.
TMPH-01705	Mucin-1/MUC1 Protein, Human, Recombinant (His)	Human	E. coli
	Mucin-1/MUC1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.2 kDa and the accession number is P15941-8.
TMPJ-00828	Tau-F Protein, Human, Recombinant Neurofibrillary tangle protein,Paired helical filament-tau,M...	Human	E. coli
	Tau proteins are proteins which contain four Tau/MAP repeats. They promote microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. The tau proteins are the product of alternative splicing from a single gene that in humans is designated MAPT. When tau proteins are def...
TMPY-00717	CEACAM1 Protein, Human, Recombinant (His) CEACAM‑1,BGP1,BGP,carcinoembryonic antigen-related cell adhe...	Human	HEK293 Cells
	CEACAM1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.8 kDa and the accession number is P13688-8.
TMPY-06707	Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-173, His) ADMCKD,PEMT,KL-6,ADMCKD1,H23AG,mucin 1, cell surface associa...	Human	HEK293 Cells
	Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-173, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.49 kDa and the accession number is P15941-8.
TMPJ-01330	CD299 Protein, Human, Recombinant (His & Flag) DC-SIGNR,L-SIGN,CD299,CD209L,LSIGN,C-type lectin domain fami...	Human	HEK293 Cells
	CD299 is also known as DC-SIGNR and CLEC4M, is a type II integral membrane protein. DC-SIGNR exists as a homotetramer, and the tandem repeat domain, also called neck domain, mediates oligermerization. Multiple human DC-SIGN/CD209 splice forms exist, generating both membrane-bound and soluble forms. DC-SIGNR is ragarded as a pathogen-recognition receptor involved in peripheral immune surveillance in liver, and probably mediate the endocytosis of pathogens which are subsequently degraded in lysoso...
TMPY-00668	APP/Protease nexin-II Protein, Human, Recombinant (hFc) CTFγ,amyloid beta (A4) precursor protein,AAA,ABPP,CVAP,APPI,...	Human	HEK293 Cells
	APP/Protease nexin-II Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 101 kDa and the accession number is P05067-8.